Jerry Mouse befriends a newly hatched duckling who can't swim and ends up protecting him against his feline nemesis, Tom.
Tom steals an egg from a mother duck's nest, but soon the resultant hatchling runs away from the cat and into a mouse hole, where it finds an able protector in Jerry.
When a duck hatches from the egg underneath Tom, the newborn (Little Quacker) is convinced Tom is his mother. Tom would like to eat the duckling; Jerry is determined to keep that from happening.
Tom is duck hunting, and he wings a little duckling that can't quite keep up with the flock. Jerry gets to the fallen duck before Tom, bandages his wing, and shelters him from Tom as he keeps running out to join his flock.
Jerry and his diapered little mouse friend flood the kitchen, then use the freezer to turn it into a skating rink. Even though Tom finds a pair of ice skates, the mice have no problem outmaneuvering him.
Tom drowns in a lake and sinks to the bottom. There, he finds a mermouse, which he tries to capture and eat.
Tom, complete with mortarboard, is teaching a kitten the basics: "cats chase mice." But Jerry keeps subverting this lesson at every opportunity.
Pluto and Pluto Junior are enjoying a lazy afternoon snooze when the playful pup tangles with a ball, a balloon, a worm, a bird, and a clothesline. Pluto rescues his son from a precarious situation, gets hung up in the process, but manages to land with a splash.
Jasper is given an ultimatum by his master: break one more thing and you're out. Rodent Jerry does his best to make sure that his tormentor "gets the boot".
Minnie gives Figaro a bath and ties a ribbon around his neck. Figaro feels like a sissy, and when he mixes it up with some alley cats, they mock him, and the leader attacks. But Figaro is so afraid that his shaking topples a series of trash cans onto the aggressor. The rest of the cats didn't see this happen, and think Figaro defeated their leader. Of course, now he's all dirty, and he needs another bath.
Tom and Jerry are in a bowling alley. Both spend a lot of time sliding on the well-polished lanes. Eventually, Jerry takes up residence among the pins and Tom tries to bowl him down.
Puss in Boots is on a mission to recover the Princess' stolen ruby from the notorious French thief, Whisperer. Reluctantly accompanied by three little kittens, Three Diablos, Puss must tame them before they endanger the mission.
The couple that owns Tom and Spike decides they can't afford to keep both. They agree that the first one to catch the mouse can stay - bad news for Jerry.
A baby woodpecker mistakes Jerry for his mother. The mouse rejects the newly hatched bird but soon finds himself protecting it against his feline nemesis, Tom.
The popular cartoon cat and mouse are thrown into a feature film. The story has the twosome trying to help an orphan girl who is being berated and exploited by a greedy guardian.
Join Donald Duck in his debut in the classic animated short The Wise Little Hen. The Little Hen is planting corn and would like to have help from Peter Pig and Donald Duck, but they refuse stating they each have a "tummy ache." When it comes time to harvest the corn, Peter Pig and Donald still refuse to help the Hen, so she and her chicks do the harvest by themselves. Finally, the hen cooks the corn and offers some to Donald and Peter Pig, but when they look more carefully they discover a surprise.
Jerry agrees to help an escaped circus lion, whose first need is food. But first they'll have to evade Tom, who heard the news bulletin and is armed with a shotgun.
Mickey accidentally takes a seal home, after it sneaks into his picnic basket. When Mickey takes a bath, the seal is discovered and Mickey returns him to the park. Later, however, Mickey and Pluto discover that the bathroom is filled with seals!
After a deadly storm, Tom and Jerry find themselves stranded on an unknown island ruled by the evil Wizard of Oz. As they try to find their way back home, they worry for their master Dorothy's safety.
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